Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation

Factors that promote pancreatic β cell growth and function are potential therapeutic targets for diabetes mellitus. In mice, genetic experiments suggest that signaling cascades initiated by insulin and IGFs positively regulate β cell mass and insulin secretion. Akt and S6 kinase (S6K) family members...

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Detalhes bibliográficos
Main Authors: Alliouachene, Samira, Tuttle, Robyn L., Boumard, Stephanie, Lapointe, Thomas, Berissi, Sophie, Germain, Stephane, Jaubert, Francis, Tosh, David, Birnbaum, Morris J., Pende, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564609/
https://ncbi.nlm.nih.gov/pubmed/18846252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35237
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