Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I

4F is an anti-inflammatory, apolipoprotein A-I (apoA-I)-mimetic peptide that is active in vivo at nanomolar concentrations in the presence of a large molar excess of apoA-I. Physiologic concentrations (∼35 μM) of human apoA-I did not inhibit the production of LDL-induced monocyte chemotactic activit...

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Detalhes bibliográficos
Main Authors: Van Lenten, Brian J., Wagner, Alan C., Jung, Chun-Ling, Ruchala, Piotr, Waring, Alan J., Lehrer, Robert I., Watson, Andrew D., Hama, Susan, Navab, Mohamad, Anantharamaiah, G. M., Fogelman, Alan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563211/
https://ncbi.nlm.nih.gov/pubmed/18621920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800075-JLR200
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