Llwytho...
RACK1 Competes with HSP90 for Binding to HIF-1α and is Required for O(2)-independent and HSP90 Inhibitor-induced Degradation of HIF-1α
Hypoxia-inducible factor 1 (HIF-1) regulates transcription in response to changes in O(2) concentration. O(2)-dependent degradation of the HIF-1α subunit is mediated by prolylhydroxylase (PHD), the von Hippel-Lindau (VHL)/Elongin C/Elongin B E3 ubiquitin ligase complex, and the proteasome. Inhibitio...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2007
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2563152/ https://ncbi.nlm.nih.gov/pubmed/17244529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.01.001 |
| Tagiau: |
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