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Perfluorocarboxylic Acids Induce Cytochrome P450 Enzymes in Mouse Liver through Activation of PPAR-α and CAR Transcription Factors

Cytochrome p450 enzymes (Cyps) are major phase-I xenobiotic-metabolizing enzymes. Cyps are regulated by many environmental chemicals and drugs. However, knowledge about regulation of Cyps by perfluorocarboxylic acids (PFCAs), which are persistent in the environment, is limited. Two days after a sing...

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Autores principales: Cheng, Xingguo, Klaassen, Curtis D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563145/
https://ncbi.nlm.nih.gov/pubmed/18648086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn147
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