The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

Transcriptional dysregulation has emerged as a core pathologic feature of Huntington's disease (HD), one of several triplet-repeat disorders characterized by movement deficits and cognitive dysfunction. Although the mechanisms contributing to the gene expression deficits remain unknown, therape...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Thomas, Elizabeth A., Coppola, Giovanni, Desplats, Paula A., Tang, Bin, Soragni, Elisabetta, Burnett, Ryan, Gao, Fuying, Fitzgerald, Kelsey M., Borok, Jenna F., Herman, David, Geschwind, Daniel H., Gottesfeld, Joel M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563081/
https://ncbi.nlm.nih.gov/pubmed/18829438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804249105
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados