Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53 – induced apoptosis

The p53 protein plays a critical role in inducing cell cycle arrest or apoptosis. Because p53 is inactivated in human gliomas, restoring p53 function is a major focus of glioma therapy. The most clinically tested strategy for replacing p53 has been adenoviral-mediated p53 gene therapy (Ad-p53). In a...

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Hlavní autoři: Nakamizo, Akira, Amano, Toshiyuko, Zhang, Wei, Zhang, Xin-Qiao, Ramdas, Latha, Liu, Ta-Jen, Bekele, B. Nebiyou, Shono, Tadahisa, Sasaki, Tomio, Benedict, William F., Sawaya, Raymond, Lang, Frederick F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Duke University Press 2008
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563050/
https://ncbi.nlm.nih.gov/pubmed/18443131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-015
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