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The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin
Diphthamide is a post-translational derivative of histidine in protein synthesis elongation factor-2 (eEF-2) that is present in all eukaryotes with no known normal physiological role. Five proteins Dph1-Dph5 are required for the biosynthesis of diphthamide. Chinese hamster ovary (CHO) cells mutated...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562939/ https://ncbi.nlm.nih.gov/pubmed/18460012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2008.01159.x |
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