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Constitutive Activation of AKT Pathway Inhibits TNF-induced Apoptosis in Mitochondrial DNA-Deficient human myelogenous leukemia ML-1a
TNF plus protein synthesis inhibitor cycloheximide induced apoptosis in human myelogenous leukemia ML-1a but not in C19, respiration minus mitochondrial DNA deficient C19 cells, derived from ML-1a. To investigate how mitochondrial DNA depletion inhibits apoptosis, we investigated AKT. Both AKT and i...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562876/ https://ncbi.nlm.nih.gov/pubmed/18468786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2008.03.020 |
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