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Constitutively active Rheb induces oncogenic transformation
Rheb (Ras homolog enriched in brain) is a component of the phosphatidylinositol 3-kinase (PI3K)–target of rapamycin (TOR) signaling pathway, functioning as a positive regulator of TOR. Constitutively active mutants of Rheb induce oncogenic transformation in cell culture. The transformed cells are la...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562864/ https://ncbi.nlm.nih.gov/pubmed/18521078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.180 |
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