Par-4 Binds to Topoisomerase 1 and Attenuates Its DNA Relaxation Activity

The regulation of DNA relaxation by topoisomerase 1 (TOP1) is essential for DNA replication, transcription, and recombination events. TOP1 activity is elevated in cancer cells, yet the regulatory mechanism restraining its activity is not understood. We present evidence that the tumor suppressor prot...

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Bibliografiske detaljer
Main Authors: Goswami, Anindya, Qiu, Shirley, Dexheimer, Thomas S., Ranganathan, Padhma, Burikhanov, Ravshan, Pommier, Yves, Rangnekar, Vivek M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562756/
https://ncbi.nlm.nih.gov/pubmed/18676842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0831
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