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Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras

Certain kindreds with low-penetrant (lp) retinoblastoma carry mutant alleles which retain partial tumor suppressor activity and we previously showed that these alleles exhibit defective, temperature-sensitive binding in yeast. To investigate the molecular basis for incomplete penetrance, we studied...

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Bibliografiske detaljer
Main Authors: Park, Yoonsoo, Kubo, Akihito, Komiya, Takefumi, Coxon, Amy, Beebe, Kristin, Neckers, Len, Meltzer, Paul S., Kaye, Frederic J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562607/
https://ncbi.nlm.nih.gov/pubmed/18677112
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