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Interleukin-10 Enhances the Therapeutic Effectiveness of a Recombinant Poxvirus-Based Vaccine in an Experimental Murine Tumor Model

Interleukin-10 (IL-10) has a wide range of in vivo biological activities and is a key regulatory cytokine of immune-mediated inflammation. The authors found that murine IL-10 given 12 hours after a recombinant vaccinia virus (rVV) containing the LacZ gene significantly enhanced the treatment of mice...

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Main Authors: Kaufman, Howard L., Rao, Jay B., Irivine, Kari R., Bronte, Vincenzo, Rosenberg, Steven A., Restifo, Nicholas P.
格式: Artigo
語言:Inglês
出版: 1999
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562555/
https://ncbi.nlm.nih.gov/pubmed/10570747
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