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Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts
The Runx genes play paradoxical roles in cancer where they can function either as dominant oncogenes or tumor suppressors according to context. We now show that the ability to induce premature senescence in primary murine embryonic fibroblasts (MEFs) is a common feature of all 3 Runx genes. However,...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562449/ https://ncbi.nlm.nih.gov/pubmed/18056452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-3016 |
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