Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors

BACKGROUND: Alpha-Synuclein (α-syn), a 140 amino acid protein associated with presynaptic membranes in brain, is a major constituent of Lewy bodies in Parkinson's disease (PD). Three missense mutations (A30P, A53T and E46K) in the α-syn gene are associated with rare autosomal dominant forms of...

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Main Authors: Wislet-Gendebien, Sabine, Visanji, Naomi P, Whitehead, Shawn N, Marsilio, Diana, Hou, Weimin, Figeys, Daniel, Fraser, Paul E, Bennett, Steffany AL, Tandon, Anurag
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562387/
https://ncbi.nlm.nih.gov/pubmed/18808659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-92
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