Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma

BACKGROUND: L-arginine is the common substrate for the two isoforms of arginase. Arginase I, highly expressed in the liver and arginase II mainly expressed in the kidney. Arginase I-producing myeloid derived suppressor cells have been shown to inhibit T-cell function by the depletion of L-arginine....

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Hauptverfasser: Tate, David J, Vonderhaar, Derek J, Caldas, Yupanqui A, Metoyer, Toye, Patterson, John R, Aviles, Diego H, Zea, Arnold H
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2008
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562378/
https://ncbi.nlm.nih.gov/pubmed/18817562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-1-14
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