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Crystal Structure of Arginase from Plasmodium falciparum and Implications for L-Arginine Depletion in Malarial Infection
The 2.15 Å resolution crystal structure of arginase from Plasmodium falciparum, the parasite that causes cerebral malaria, is reported in complex with the boronic acid inhibitor 2(S)-amino-6-boronohexanoic acid (ABH; K(d) = 11 μM). This is the first crystal structure of a parasitic arginase. Various...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2894275/ https://ncbi.nlm.nih.gov/pubmed/20527960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100390z |
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