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Total Synthesis of Enantiopure (+)-γ -Lycorane Using Highly Efficient Pd-Catalyzed Asymmetric Allylic Alkylation

Highly efficient short total synthesis of γ -lycorane (>99% ee, 41% overall yield) was achieved by using the asymmetric allylic alkylation in the key step catalyzed by palladium complexes with novel chiral biphenol-based monodentate phosphoramidite ligands.

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Bibliografiske detaljer
Main Authors: Chapsal, Bruno D., Ojima, Iwao
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562274/
https://ncbi.nlm.nih.gov/pubmed/16562900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol060181v
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