Critical and Distinct Roles of p16 and Telomerase in Regulating the Proliferative Life Span of Normal Human Prostate Epithelial Progenitor Cells

Normal human prostate (NHP) epithelial cells undergo senescence in vitro and in vivo, but the underlying molecular mechanisms remain obscure. Here we show that the senescence of primary NHP cells, which are immunophenotyped as intermediate basal-like cells expressing progenitor cell markers CD44, α2...

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Detalhes bibliográficos
Main Authors: Bhatia, Bobby, Jiang, Ming, Suraneni, Mahipal, Patrawala, Lubna, Badeaux, Mark, Schneider-Broussard, Robin, Multani, Asha S., Jeter, Collene R., Calhoun-Davis, Tammy, Hu, Limei, Hu, Jianhua, Tsavachidis, Spiridon, Zhang, Wei, Chang, Sandy, Hayward, Simon W., Tang, Dean G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562067/
https://ncbi.nlm.nih.gov/pubmed/18662989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803467200
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