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Disruption of the Plasmodium falciparum PfPMT Gene Results in a Complete Loss of Phosphatidylcholine Biosynthesis via the Serine-Decarboxylase-Phosphoethanolamine-Methyltransferase Pathway and Severe Growth and Survival Defects

Biochemical studies in the human malaria parasite, Plasmodium falciparum, indicated that in addition to the pathway for synthesis of phosphatidylcholine from choline (CDP-choline pathway), the parasite synthesizes this major membrane phospholipid via an alternative pathway named the serine-decarboxy...

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Библиографические подробности
Главные авторы: Witola, William Harold, El Bissati, Kamal, Pessi, Gabriella, Xie, Changan, Roepe, Paul D., Mamoun, Choukri Ben
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562060/
https://ncbi.nlm.nih.gov/pubmed/18694927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804360200
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