Disruption of the Plasmodium falciparum PfPMT Gene Results in a Complete Loss of Phosphatidylcholine Biosynthesis via the Serine-Decarboxylase-Phosphoethanolamine-Methyltransferase Pathway and Severe Growth and Survival Defects

Biochemical studies in the human malaria parasite, Plasmodium falciparum, indicated that in addition to the pathway for synthesis of phosphatidylcholine from choline (CDP-choline pathway), the parasite synthesizes this major membrane phospholipid via an alternative pathway named the serine-decarboxy...

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Detalhes bibliográficos
Main Authors: Witola, William Harold, El Bissati, Kamal, Pessi, Gabriella, Xie, Changan, Roepe, Paul D., Mamoun, Choukri Ben
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562060/
https://ncbi.nlm.nih.gov/pubmed/18694927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804360200
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