Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial

Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing adenomas with little additional toxicities, suggesting a strategy to improve risk to benefit ratios for preventing recurrent adenomas. Three hundred seventy-five patients with histor...

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Hauptverfasser: Meyskens, Frank L., McLaren, Christine E., Pelot, Daniel, Fujikawa-Brooks, Sharon, Carpenter, Philip M., Hawk, Ernest, Kelloff, Gary, Lawson, Michael J., Kidao, Jayashri, McCracken, John, Albers, C. Gregory, Ahnen, Dennis J., Turgeon, D. Kim, Goldschmid, Steven, Lance, Peter, Hagedorn, Curt H., Gillen, Daniel L., Gerner, Eugene W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562024/
https://ncbi.nlm.nih.gov/pubmed/18841250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-08-0042
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