Formation of Two Novel Estrogen Guanine Adducts and HPLC/MS Detection of 4-Hydroxyestradiol-N(7)-Guanine in Human Urine

Estrogen-DNA adducts are potential biomarkers for assessing the risk of developing of a number of hormonally-modified cancers, including breast cancer. Formation of the 4-hydroxyestradiol-N(7)-guanine (4-OHE(2)-N(7)-guanine) adduct from reaction of estradiol-3,4-quinone with DNA and its detection in...

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Hauptverfasser: Bransfield, Leslie A., Rennie, Alissa, Visvanathan, Kala, Odwin, Shelly-Ann, Kensler, Thomas W., Yager, James D., Friesen, Marlin D., Groopman, John D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561950/
https://ncbi.nlm.nih.gov/pubmed/18582124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800145w
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