Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation

PURPOSE AND DESIGN: Mechanism(s) by which the multi-kinase inhibitor sorafenib and the histone deacetylase inhibitor vorinostat interact to kill hepatic, renal and pancreatic adenocarcinoma cells have been defined. RESULTS: Low doses of sorafenib and vorinostat interacted in vitro in a synergistic f...

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Hoofdauteurs: Zhang, Guo, Park, Margaret A., Mitchell, Clint, Hamed, Hossein, Rahmani, Mohammed, Martin, Aditi Pandya, Curiel, David T., Yacoub, Adly, Graf, Martin, Lee, Ray, Roberts, John D., Fisher, Paul B., Grant, Steven, Dent, Paul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561272/
https://ncbi.nlm.nih.gov/pubmed/18765530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0469
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