Maraviroc: in vitro assessment of drug–drug interaction potential

AIMS: To characterize the cytochrome P450 enzyme(s) responsible for the N-dealkylation of maraviroc in vitro, and predict the extent of clinical drug–drug interactions (DDIs). METHODS: Human liver and recombinant CYP microsomes were used to identify the CYP enzyme responsible for maraviroc N-dealkyl...

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Detalhes bibliográficos
Main Authors: Hyland, Ruth, Dickins, Maurice, Collins, Claire, Jones, Hannah, Jones, Barry
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561101/
https://ncbi.nlm.nih.gov/pubmed/18647303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03198.x
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