Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction

AIMS: The aim of this study was to explore and optimize the in vitro and in silico approaches used for predicting clinical DDIs. A data set containing clinical information on the interaction of 20 Pfizer compounds with ketoconazole was used to assess the success of the techniques. METHODS: The study...

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Detalhes bibliográficos
Main Authors: Youdim, Kuresh A, Zayed, Aref, Dickins, Maurice, Phipps, Alex, Griffiths, Michelle, Darekar, Amanda, Hyland, Ruth, Fahmi, Odette, Hurst, Susan, Plowchalk, David R, Cook, Jack, Guo, Feng, Obach, R Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2432478/
https://ncbi.nlm.nih.gov/pubmed/18279465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.03070.x
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