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Asymmetric Synthesis of Inhibitors of Glycinamide Ribonucleotide Transformylase
Glycinamide ribonucleotide transformylase (GAR Tfase) catalyzes the first of two formyl transfer steps in the de novo purine biosynthetic pathway that require folate cofactors and has emerged as a productive target for antineoplastic therapeutic intervention. The asymmetric synthesis and evaluation...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2559975/ https://ncbi.nlm.nih.gov/pubmed/18686942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800555h |
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