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Human Glycinamide Ribonucleotide Transformylase: Active Site Mutants as Mechanistic Probes
Human glycinamide ribonucleotide transformylase (GART) (EC2.1.2.2) is a validated target for cancer chemotherapy, but mechanistic studies of this therapeutically important enzyme are limited. Site-directed mutagenesis, initial velocity studies, pH-rate studies, and substrate binding studies have bee...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518408/ https://ncbi.nlm.nih.gov/pubmed/17198385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0619270 |
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