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Discovery of a Potent, Nonpolyglutamatable Inhibitor of Glycinamide Ribonucleotide Transformylase
Glycinamide ribonucleotide transformylase (GAR Tfase) catalyzes the first of two formyl transfer steps in the de novo purine biosynthetic pathway that require folate cofactors. Herein we report the discovery of a potent, non-polyglutamatable, and selective inhibitor of GAR Tfase. Compound 12, which...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2531195/ https://ncbi.nlm.nih.gov/pubmed/16686541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0601147 |
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