Discovery of a Potent, Nonpolyglutamatable Inhibitor of Glycinamide Ribonucleotide Transformylase

Glycinamide ribonucleotide transformylase (GAR Tfase) catalyzes the first of two formyl transfer steps in the de novo purine biosynthetic pathway that require folate cofactors. Herein we report the discovery of a potent, non-polyglutamatable, and selective inhibitor of GAR Tfase. Compound 12, which...

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Bibliografiske detaljer
Main Authors: DeMartino, Jessica K., Hwang, Inkyu, Xu, Lan, Wilson, Ian A., Boger, Dale L.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531195/
https://ncbi.nlm.nih.gov/pubmed/16686541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0601147
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