Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to Ionizing Radiation

In response to DNA damage, the ATM protein kinase activates signal transduction pathways essential for coordinating cell cycle progression with DNA repair. In the human disease ataxia-telangiectasia, mutation of the ATM gene results in multiple cellular defects, including enhanced sensitivity to ion...

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Hauptverfasser: Rainey, Michael D., Charlton, Maura E., Stanton, Robert V., Kastan, Michael B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2559948/
https://ncbi.nlm.nih.gov/pubmed/18794134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0763
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