Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model

OBJECTIVE: For the inflammation characteristic of rheumatoid arthritis, the relative contribution of mediators produced locally in the synovium versus those circulating systemically is unknown. Complement factor C3 is made in rheumatoid synovium and has been proposed to be a crucial driver of inflam...

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Detalhes bibliográficos
Main Authors: Monach, Paul A, Verschoor, Admar, Jacobs, Jonathan P, Carroll, Michael C, Wagers, Amy J, Benoist, Christophe, Mathis, Diane
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2007
Assuntos:
Experimental Arthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2559465/
https://ncbi.nlm.nih.gov/pubmed/17763447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.22859
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