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The Natural Product Avrainvillamide Binds to the Oncoprotein Nucleophosmin
Here we present evidence that (+)-avrainvillamide, a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Among other effects, nucleophosmin is known to regulate t...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2557551/ https://ncbi.nlm.nih.gov/pubmed/17958425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja075327f |
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