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The Natural Product Avrainvillamide Binds to the Oncoprotein Nucleophosmin

Here we present evidence that (+)-avrainvillamide, a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Among other effects, nucleophosmin is known to regulate t...

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Main Authors: Wulff, Jeremy E., Siegrist, Romain, Myers, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2557551/
https://ncbi.nlm.nih.gov/pubmed/17958425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja075327f
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