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Synthesis of 3-Iodoindoles by the Pd/Cu-Catalyzed Coupling of N,N-Dialkyl-2-iodoanilines and Terminal Acetylenes, Followed by Electrophilic Cyclization

3-Iodoindoles have been prepared in excellent yields by coupling terminal acetylenes with N,N-dialkyl-o-iodoanilines in the presence of a Pd/Cu catalyst and subsequent electrophilic cyclization of the resulting N,N-dialkyl-o-(1-alkynyl)anilines using I(2) in CH(2)Cl(2). Aryl-, vinylic-, alkyl- and s...

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Autors principals: Yue, Dawei, Yao, Tuanli, Larock, Richard C.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556959/
https://ncbi.nlm.nih.gov/pubmed/16388618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo051549p
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