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Mutations within Helix I of Twist1 Result in Distinct Limb Defects and Variation of DNA-Binding Affinities

Twist1 is a basic helix-loop-helix (bHLH) factor that plays an important role in limb development. Haploinsufficiency of Twist1 results in polydactyly via the inability of Twist1 to antagonistically regulate the related factor Hand2. The mechanism modulating Twist1-Hand2 antagonism is via phosphoreg...

詳細記述

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書誌詳細
主要な著者: Firulli, Beth A., Redick, Bradley A., Conway, Simon J., Firulli, Anthony B.
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556885/
https://ncbi.nlm.nih.gov/pubmed/17652084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M702613200
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