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Mutations within Helix I of Twist1 Result in Distinct Limb Defects and Variation of DNA-Binding Affinities

Twist1 is a basic helix-loop-helix (bHLH) factor that plays an important role in limb development. Haploinsufficiency of Twist1 results in polydactyly via the inability of Twist1 to antagonistically regulate the related factor Hand2. The mechanism modulating Twist1-Hand2 antagonism is via phosphoreg...

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Detalhes bibliográficos
Main Authors: Firulli, Beth A., Redick, Bradley A., Conway, Simon J., Firulli, Anthony B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556885/
https://ncbi.nlm.nih.gov/pubmed/17652084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M702613200
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