Synaptic NMDA receptor activity boosts intrinsic antioxidant defences

Intrinsic antioxidant defences are important for neuronal longevity. We show that synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosts antioxidant defences through changes to the thioredoxin-peroxiredoxin system. Synaptic activity enhances thioredoxin activity, facilitates the reduc...

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Autores principales: Papadia, Sofia, Soriano, Francesc X., Léveillé, Frédéric, Martel, Marc-Andre, Dakin, Kelly A., Hansen, Henrik H., Kaindl, Angela, Sifringer, Marco, Fowler, Jill, Stefovska, Vanya, Mckenzie, Grahame, Craigon, Marie, Corriveau, Roderick, Ghazal, Peter, Horsburgh, Karen, Yankner, Bruce A., Wyllie, David J. A., Ikonomidou, Chrysanthy, Hardingham, Giles E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556874/
https://ncbi.nlm.nih.gov/pubmed/18344994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn2071
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