Synaptic NMDA receptor activity boosts intrinsic antioxidant defences

Intrinsic antioxidant defences are important for neuronal longevity. We show that synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosts antioxidant defences through changes to the thioredoxin-peroxiredoxin system. Synaptic activity enhances thioredoxin activity, facilitates the reduc...

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書誌詳細
主要な著者: Papadia, Sofia, Soriano, Francesc X., Léveillé, Frédéric, Martel, Marc-Andre, Dakin, Kelly A., Hansen, Henrik H., Kaindl, Angela, Sifringer, Marco, Fowler, Jill, Stefovska, Vanya, Mckenzie, Grahame, Craigon, Marie, Corriveau, Roderick, Ghazal, Peter, Horsburgh, Karen, Yankner, Bruce A., Wyllie, David J. A., Ikonomidou, Chrysanthy, Hardingham, Giles E.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556874/
https://ncbi.nlm.nih.gov/pubmed/18344994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn2071
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