Synaptic NMDA receptor activity boosts intrinsic antioxidant defences

Intrinsic antioxidant defences are important for neuronal longevity. We show that synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosts antioxidant defences through changes to the thioredoxin-peroxiredoxin system. Synaptic activity enhances thioredoxin activity, facilitates the reduc...

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Detalhes bibliográficos
Main Authors: Papadia, Sofia, Soriano, Francesc X., Léveillé, Frédéric, Martel, Marc-Andre, Dakin, Kelly A., Hansen, Henrik H., Kaindl, Angela, Sifringer, Marco, Fowler, Jill, Stefovska, Vanya, Mckenzie, Grahame, Craigon, Marie, Corriveau, Roderick, Ghazal, Peter, Horsburgh, Karen, Yankner, Bruce A., Wyllie, David J. A., Ikonomidou, Chrysanthy, Hardingham, Giles E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556874/
https://ncbi.nlm.nih.gov/pubmed/18344994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn2071
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