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The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation

Phosphatidylinositol 3-kinases (PI3Ks) play a critical role in regulating B cell receptor– and T cell receptor–mediated signaling. However, their role in natural killer (NK) cell development and functions is not well understood. Using mice expressing p110δ(D910A), a catalytically inactive p110δ, we...

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Detalhes bibliográficos
Main Authors: Guo, Hailong, Samarakoon, Asanga, Vanhaesebroeck, Bart, Malarkannan, Subramaniam
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556795/
https://ncbi.nlm.nih.gov/pubmed/18809712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072327
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