PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

E-selectin binding to P-selectin glycoprotein ligand-1 (PSGL-1) can activate the β(2) integrin lymphocyte function-associated antigen-1 by signaling through spleen tyrosine kinase (Syk). This signaling is independent of Gα(i)-protein–coupled receptors, results in slow rolling, and promotes neutrophi...

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Hauptverfasser: Zarbock, Alexander, Abram, Clare L., Hundt, Matthias, Altman, Amnon, Lowell, Clifford A., Ley, Klaus
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556779/
https://ncbi.nlm.nih.gov/pubmed/18794338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072660
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