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PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling
E-selectin binding to P-selectin glycoprotein ligand-1 (PSGL-1) can activate the β(2) integrin lymphocyte function-associated antigen-1 by signaling through spleen tyrosine kinase (Syk). This signaling is independent of Gα(i)-protein–coupled receptors, results in slow rolling, and promotes neutrophi...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2556779/ https://ncbi.nlm.nih.gov/pubmed/18794338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072660 |
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