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A Single Amino Acid Residue Defines the Difference in Ovalicin Sensitivity between Type I and II Methionine Aminopeptidases
TNP-470, the first anti-angiogenic small molecule to enter clinical trials, targets methionine aminopepti-dase-2 (MetAP-2), a metalloprotease that cleaves the N-terminal methionine of proteins. Previously, biochemical binding, in vivo yeast studies, and structural studies of human methionine aminope...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2556556/ https://ncbi.nlm.nih.gov/pubmed/14676204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M307246200 |
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