PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein deletion and subsequent activation of the PI3K/Akt signaling pathway are common in cancer. Here we show that PTEN inactivation in human T cell acute lymphoblastic leukemia (T-ALL) cells is not always synonymous with...

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Autors principals: Silva, Ana, Yunes, J. Andrés, Cardoso, Bruno A., Martins, Leila R., Jotta, Patrícia Y., Abecasis, Miguel, Nowill, Alexandre E., Leslie, Nick R., Cardoso, Angelo A., Barata, Joao T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556239/
https://ncbi.nlm.nih.gov/pubmed/18830414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34616
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