Focal Adhesion Kinase (FAK)-related Non-kinase Inhibits Myofibroblast Differentiation through Differential MAPK Activation in a FAK-dependent Manner

Transforming growth factor (TGF)-β1 induces fibroblast transdifferentiation to myofibroblasts, a process that requires the involvement of integrin-mediated signaling and focal adhesion kinase (FAK). FAK-related non-kinase (FRNK) is known for its role in inhibiting integrin-mediated cell migration; h...

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Bibliographic Details
Main Authors: Ding, Qiang, Gladson, Candece L., Wu, Hongju, Hayasaka, Haurko, Olman, Mitchell A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556008/
https://ncbi.nlm.nih.gov/pubmed/18669633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803645200
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