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Biochemical and Structural Characterization of the Pak1-LC8 Interaction

Pak1 (p21-activated kinase-1) and the dynein light chain, LC8, are overexpressed in breast cancer, and their direct interaction has been proposed to regulate tumor cell survival. These effects have been attributed in part to Pak1-mediated phosphorylation of LC8 at serine 88. However, LC8 is homodime...

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Detalhes bibliográficos
Main Authors: Lightcap, Christine M., Sun, Shangjin, Lear, James D., Rodeck, Ulrich, Polenova, Tatyana, Williams, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556000/
https://ncbi.nlm.nih.gov/pubmed/18650427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800758200
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