Biochemical and Structural Characterization of the Pak1-LC8 Interaction

Pak1 (p21-activated kinase-1) and the dynein light chain, LC8, are overexpressed in breast cancer, and their direct interaction has been proposed to regulate tumor cell survival. These effects have been attributed in part to Pak1-mediated phosphorylation of LC8 at serine 88. However, LC8 is homodime...

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Bibliographic Details
Main Authors: Lightcap, Christine M., Sun, Shangjin, Lear, James D., Rodeck, Ulrich, Polenova, Tatyana, Williams, John C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556000/
https://ncbi.nlm.nih.gov/pubmed/18650427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800758200
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