Epidermal Growth Factor–induced Enhancement of Glioblastoma Cell Migration in 3D Arises from an Intrinsic Increase in Speed But an Extrinsic Matrix- and Proteolysis-dependent Increase in Persistence

Epidermal growth factor (EGF) receptor-mediated cell migration plays a vital role in invasion of many tumor types. EGF receptor ligands increase invasiveness in vivo, but it remains unclear how consequent effects on intrinsic cell motility behavior versus effects on extrinsic matrix properties integ...

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Main Authors: Kim, Hyung-Do, Guo, Tiffany W., Wu, Angela P., Wells, Alan, Gertler, Frank B., Lauffenburger, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2555959/
https://ncbi.nlm.nih.gov/pubmed/18632979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-05-0501
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