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Capturing Hammerhead Ribozyme Structures in Action by Modulating General Base Catalysis

We have obtained precatalytic (enzyme–substrate complex) and postcatalytic (enzyme–product complex) crystal structures of an active full-length hammerhead RNA that cleaves in the crystal. Using the natural satellite tobacco ringspot virus hammerhead RNA sequence, the self-cleavage reaction was modul...

詳細記述

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書誌詳細
主要な著者: Chi, Young-In, Martick, Monika, Lares, Monica, Kim, Rosalind, Scott, William G, Kim, Sung-Hou
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553840/
https://ncbi.nlm.nih.gov/pubmed/18834200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060234
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