Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation

Nonuniform, mosaic expression patterns of transgenes are often linked to transcriptional silencing, triggered by epigenetic modifications of the exogenous DNA. Such phenotypes are common phenomena in genetically engineered cells and organisms. They are widely attributed to features of transgenic tra...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Kaufman, Weimin L., Kocman, Ibrahim, Agrawal, Vishal, Rahn, Hans-Peter, Besser, Daniel, Gossen, Manfred
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2008
Konular:
Methods Online
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553579/
https://ncbi.nlm.nih.gov/pubmed/18682524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn508
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