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Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation
Nonuniform, mosaic expression patterns of transgenes are often linked to transcriptional silencing, triggered by epigenetic modifications of the exogenous DNA. Such phenotypes are common phenomena in genetically engineered cells and organisms. They are widely attributed to features of transgenic tra...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2553579/ https://ncbi.nlm.nih.gov/pubmed/18682524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn508 |
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