Non-conservative homologous recombination in human B lymphocytes is promoted by activation-induced cytidine deaminase and transcription

During secondary immunoglobulin (Ig) diversification in vertebrates, the sequence of the variable region of Ig genes may be altered by templated or non-templated mechanisms. In both cases, cytidine deamination by activation-induced cytidine deaminase (AID) in the transcribed Ig loci leads to DNA les...

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Autori principali: Mierau, Maren, Drexler, Guido A., Kutzera, André, Braunschmidt, Kerstin, Ellwart, Joachim, Eckardt-Schupp, Friederike, Fritz, Eberhard, Bachl, Jürgen, Jungnickel, Berit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2008
Soggetti:
Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553578/
https://ncbi.nlm.nih.gov/pubmed/18757891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn542
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